Dr. Shentu has been engaged in clinical, scientific research and teaching of cataract and intraocular lens (IOL) for more than 20 years. She is particularly interested in the genetic pathology of cataract, and her lab revealed lots of the cellular function of mutated proteins and pathologic mechanisms of candidate genes related to congenital cataract and age-related cataract.
At lens epithelia cell level, she was able to identify the novel roles of cell apoptosis and autophagy processes in cataract formation.
At animal level, her lab generated different genetic and diseases model to discover the cataract-related mechanisms in zebrafish, mouse, rabbit and ground squirrel.
In addition, her lab has been continuously working on medicine applications in cataract-related oxidative-stress-induced injury and dysfunctional autophagy.
Xiajing Tang(#), Xiyuan Ping(#), Chenqi Luo, Xiaoning Yu, Yelei Tang*, Xingchao Shentu*. Dystrophia canthorum in Waardenburg syndrome with a novel MITF mutation. International Journal of Ophthalmology. Int J Ophthalmol 2020;13(7):1054-1059.
Hao Yang(#), Yilei Cui, Yelei Tang, Xiaoning Yu, Jiayue Zhou, Qichuan Yin, Xingchao Shentu*. Cytoprotective role of humanin in lens epithelial cell oxidative-stress-induced injury. Molecular Medicine Reports 2020 Aug;22(2):1467-1479.
Haijie Han(#), Qichuan Yin(#), Xiajing Tang, Xiaoning Yu, Qiang Gao, Yelei Tang, Andrzej Grzybowski, Ke Yao, Jian Ji*, Xingchao Shentu*. Development of mucoadhesive cationic polypeptide micelles for sustained cabozantinib release and inhibition of corneal neovascularization. Journal of Materials Chemistry B. 2020 Jun 21;8(23):5143-5154.
Yilei Cui(#), Xiaoning Yu, Xin Zhang, Yelei Tang, Xiajing Tang, Hao Yang, Xiyuan Ping, Jing Wu, Qichuan Yin, Jiayue Zhou, Xiayan Xu, XingChao Shentu*. Association of IGF1R polymorphisms (rs1546713) with susceptibility to age-related cataract in a Han Chinese population. Int J Ophthalmol 2020;13(3):374-381.
Xiayan Xu(#), Jing Wu, Xiaoning Yu, Yelei Tang, Xiajing Tang and Xingchao Shentu*. Regional differences in the global burden of age-related macular degeneration. BMC Public Health (2020) 20:410.
Xiayan Xu(#), Xin Zhang, Yilei cui, Hao Yang, Xiyuan ping, Jing Wu, Xiaoning Yu, Xiuming Jin, Xiaodan Huang & Xingchao Shentu*. Three novel variants identified within ECM-related genes in chinese Han keratoconus patients. Scientific Reports (2020) 10:5844.
Jing Wu(#), Xiaoning Yu, Xiyuan Ping, Xiayan Xu, Yilei Cui, Hao Yang, Jiayue Zhou, Qichuan Yin & Xingchao Shentu*. Socioeconomic disparities in the global burden of glaucoma: an analysis of trends from 1990 to 2016. Graefe's Archive for Clinical and Experimental Ophthalmology (2020) 258:587–594.
Jing Wu(#), Jiayue Zhou, Xiyuan Ping, Xiayan Xu, Yilei Cui, Hao Yang, Qichuan Yin, Xingchao Shentu*. Scanning and transmission electron microscopy study of anterior lens epithelium in presenile cataract. Int Ophthalmol 2020 Jun;40(6):1411-1418.
Xingchao Shentu*, Ya-Lan Cheng, Zhi-Qing Chen, Zhao-An Su, Li Zhang. Differences in Intraocular Lens Power Calculation in Patients With Sub-Foveal Choroidal Neovascularization. Int J Ophthalmol. 2019 Jan 18;12(1):172-174.
Xiaoning Yu(#), Xiyuan Ping(#), Xin Zhang, Yilei Cui, Hao Yang, Xiajing Tang, Yelei Tang, Xingchao Shentu*. The impact of GJA8 SNPs on susceptibility to age-related cataract. Human Genetics. 2018 Dec;137(11-12):897-904.
Xingchao Shentu(#), Xiyuan Ping, Yalan Cheng, Xin Zhang, Yelei Tang, Xiajing Tang. Hydrogen peroxide-induced apoptosis of human lens epithelial cells is inhibited by parthenolide. Int J Ophthalmol 2018;11(1):12-17.
Ya-nan Zhu(#), Chaohui Sun, Xin Zhang, Xingchao Shentu*.Ptosis induced by topical steroid eye drops: Two cases reports. Medicine (Baltimore). 2017 Dec;96(51): e9288.
Yan Weng(#), Ren YP, Zhang L, Huang XD, Xingchao Shentu*. An alternative technique for Descemet’s membrane detachment following phacoemulsification: case report and review of literature. BMC Ophthalmol. 2017; 17: 109.
Qi Miao(#), Xiyuan Ping, Xiajing Tang, Li Zhang, Xin Zhang, Yalan Cheng, Xingchao Shentu*. Experimental assessment of novel PAX6 splicing mutations in two Chinese families with aniridia.Gene.630 (2017) 44–48.
Yu X(#), Chen B, Zhang X, Shentu XC*.Identification of seven novel ZNF469 mutations in keratoconus patients in a Han Chinese population. Mol Vis. 2017 Apr 28;23:296-305.
Shentu Xingchao(#), Zhang, Xin, Tang Xiajing,Yu Xiaoning*.Coaxial Microincision Cataract Surgery versus Standard Coaxial Small-Incision Cataract Surgery:A Meta-Analysis of Randomized Controlled Trials. PLoS One.2016,11(1):e0146676-e0146676.
Ye-lei Tang(#), Ya-lan Cheng, Yu-ping Ren, Xiao-ning Yu, Xing-Chao Shentu*. Metabolic syndrome risk factors and dry eye syndrome:a Meta-analysis. Int J Ophthalmol 2016;9(7):1038–1045.
Xingchao Shentu(#)*, Qi Miao, Xiajing Tang, Houfa Yin, Yingying Zhao. Identification and Functional Analysis of aNovel MIP Gene Mutation Associated with Congenital Cataract in a Chinese Family. PLos One.2015,10(5).
Shentu Xing-Chao(#), Zhao Su-Juan, Zhang, Li*, Miao Qi. A novel p.R890C mutation in EPHA2 gene associated with progressive childhood posterior cataract in a Chinese family. Int J Ophthalmol. 2013,6(1):34-38.
Shentu Xing-Chao(#), Zhu, Ya-Nan, Gao Ying-Hui, Zhao Su-Juan, Tang Ye-Lei*. Electron microscopic investigation of anterior lens capsule in an individual with true exfoliation. Int J Ophthalmol. 2013,6(4):553-556.
Zhao Su-Juan(#), Zhu Ya-Nan, Shentu Xing-Chao*, Miao Qi. Chinese family with atypical granular corneal dystrophy type I caused by the typical R555W mutation in TGFBI. Int J Ophthalmol. 2013,6(4):458-462.
Mechanism of Cx50-Atg16L1 complex regulating formation of the phagophore in human lens epithelial cells mediated by Wipi2 and the related drug targets. Founding Source: National Natural Science Foundation of China.
GJA8-Atg proteins induce abnormal autophagy and its related molecular mechanism in lens epithelial cells. Founding Source: National Natural Science Foundation of China.
Study of importinα3 and its epigenetic regulation in senescent lens epithelial cells. Founding Source: National Natural Science Foundation of China.
