Dr. Fu developed a novel method to generate lens from iPSCs and use this method in pathological mechanism investigation and drug screening for cataracts, investigate the association of air pollution and ocular diseases and the potential molecular mechanism.
Lens regeneration and its application in cataract treatment, mechanism investigation of air pollution effects on ocular diseases.
Lyu D, Almansoob S, Chen H, Ye Y, Song F, Zhang L, Qin Z, Tang Q, Yin H, Xu W, Chen Z, Yao K*, Fu Q*. Transcriptomic profiling of human corneal epithelial cells exposed to airborne fine particulate matter (PM2.5). Transcriptomic profiling of human corneal epithelial cells exposed to airborne fine particulate matter (PM2.5). Ocul Surf. 2020 Jun 18:S1542-0124(20)30100-2. doi: 10.1016/j.jtos.2020.06.003. Online ahead of print.
Fu Q#, Qin Z#, Zhang L, Lyu D, Tang Q, Yin H, Chen Z, Yao K*. A new long noncoding RNA ALB regulates autophagy by enhancing the transformation of LC3BⅠ to LC3BⅡ during human lens development. Molecular Therapy Nucleic Acid. 2017.10 epub ahead.
Fu Q#, Mo Z#, Lyu D, Zhang L, Qin Z, Tang Q, Yin H, Xu P, Wu L, Lou X, Chen Z*, Yao K*. Air pollution and outpatient visits for conjunctivitis: A case-crossover study in Hangzhou, China. Environ Pollut. 2017 Sep 22. pii: S0269-7491(17)33314-6. doi: 10.1016/j.envpol.2017.08.109
Fu Q#, Lyu D#, Zhang L, Qin Z, Tang Q, Yin H, Lou X, Chen Z*, Yao K*. Airborne particulate matter (PM2.5) triggers autophagy in human corneal epithelial cell line.Environ Pollut. 2017 Aug;227:314-322. doi: 10.1016/j.envpol. 2017.04.078. Epub 2017 May 4.
Fu Q#, Qin Z#, Jin X, Zhang L, Chen Z, He J, Ji J*, Yao K*.Generation of Functional Lentoid Bodies From Human Induced Pluripotent Stem Cells Derived From Urinary Cells.Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):517-527. doi: 10.1167/iovs.16-20504.
Qin Z#, Fu Q#, Zhang L, Yin H, Jin X, Tang Q, Lyu D, Yao K*. Proliferative effects of histamine on primary human pterygium fibroblasts. Mediators Inflam. 2016;2016:9862496.
Fu Q, Qin Z, Yu J, Yu Y, Tang Q, Lyu D, Zhang L, Chen Z, Yao K*. Effects of senescent lens epithelial cells on the severity of age-related cortical cataract in humans: A case-control study. Medicine (Baltimore). 2016 Jun;95(25):e3869.doi: 10.1097/MD.0000000000003869.
Willems C#, Fu Q#, Roose H, Mertens F, Cox B, Chen J, Vankelecom H*. Regeneration in the Pituitary After Cell-Ablation Injury: Time-Related Aspects and Molecular Analysis. Endocrinology. 2016 Feb; 157(2):705-21. doi: 10.1210/en.2015-1741. Epub 2015 Dec 14.
Fu Q, Vankelecom H*. Regenerative capacity of the adult pituitary: multiple mechanisms of lactotrope restoration after transgenic ablation. Stem Cells Dev. 2012; 21(18):3245-57.
Fu Q, Gremeaux L, Luque RM, Liekens D, Chen J, Buch T, Waisman A,Kineman R, Vankelecom H*. The adult pituitary shows stem/progenitor cell activation in response to injury and is capable of regeneration. Endocrinology. 2012; 153(7):3224-35.
Fu Q, Dai H, He P, Hu W, Fan Y, Zhang W, Chen Z*. The H3 receptor antagonist clobenpropit protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells. Pharmazie. 2010; 65(4):257-60.
Fu Q, Dai H, Hu W, Fan Y, Shen Y, Zhang W, Chen Z*. Carnosine protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells. Cell Mol Neurobiol. 2008; 28(2):307-16.
